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Researchers Discover Compound That Reverses Alzheimer’s and Parkinson’s Symptoms

Study in flies could have major implications for human disease.

Alzheimer’s and Parkinson’s disease are the two most common neurodegenerative disorders worldwide and cause untold suffering to millions of patients and their families. Treatments for these diseases are limited, and no cures exist. Now, a new study describes an innovative strategy that reverses symptoms in these neurodegenerative diseases – at least in fruit flies which had been genetically altered to model the diseases.

“The novel approach we used has significant translational implications,” said one of the lead authors, Robert Schwarcz, a researcher in the Department of Psychiatry at the University of Maryland School of Medicine. “If we can duplicate these effects in patients, we could benefit a lot of people.”

Schwarcz collaborated with geneticist Flaviano Giorgini at the University of Leicester in England. The study was published today in the journal Proceedings of the National Academy of Sciences.

The researchers focused on metabolites related to the amino acid tryptophan. When tryptophan degrades in the body, it breaks down into several compounds that have biological activities in the nervous system. One of these, 3-hydroxykynurenine (3-HK), has neurotoxic properties whereas another, named kynurenic acid (KYNA), has the ability to prevent nerve cell degeneration. The relative abundance of these two compounds in the brain may be critical in Alzheimer’s and Parkinson’s disease, and also Huntington’s disease.

Image of an alzheimer's brain.

Alzheimer’s and Parkinson’s disease are the two most common neurodegenerative disorders worldwide and cause untold suffering to millions of patients and their families. Image is for illustrative purposes only.

Schwarcz, Giorgini and their colleagues gave the insects a chemical that selectively inhibits tryptophan-2,3-dioxygenase (TDO), an enzyme that controls the relationship between 3-HK and KYNA. This treatment shifted metabolism towards more KYNA, improved movement, and lengthened lifespan in the fly models of the diseases.

“A key finding of our study is that we can improve “symptoms” in fruit fly models of Alzheimer’s and Parkinson’s disease by feeding them a drug-like chemical,” said another co-author, Carlo Breda of the University of Leicester. “Our experiments have identified TDO as a very promising new drug target.”

The next steps will involve testing of the new concept in humans and to examine whether the treatment works for neurodegenerative diseases.

ABOUT THIS GENETICS RESEARCH

Source: David Kohn – University of Maryland School of Medicine
Image Source: The image is in the public domain.
Original Research: Full open access research for “Tryptophan-2,3-dioxygenase (TDO) inhibition ameliorates neurodegeneration by modulation of kynurenine pathway metabolites” by Carlo Breda, Korrapati V. Sathyasaikumar, Shama Sograte Idrissi, Francesca M. Notarangelo, Jasper G. Estranero, Gareth G. L. Moore, Edward W. Green, Charalambos P. Kyriacou, Robert Schwarcz, and Flaviano Giorgini in PNAS. Published online April 25 2016 doi:10.1073/pnas.1604453113

 

Human brain keeps memories tidy by pruning inaccurate ones

by Michael Hotchkiss




Princeton graduate student Ghootae Kim discusses the memory research with Turk-Browne and Kenneth Norman, a Princeton professor of psychology and the Princeton Neuroscience Institute. The researchers’ experiment involved 24 adults whose brain was monitored by a functional magnetic resonance imaging (fmri) machine …More

Every Child Can Win the Memory Game

Article for Edutopia – The George Lucas Educational Foundation

Photo credit: Caroline O’Brien

As a student, I had great difficulty concentrating during lesson time and consequently didn’t retain much knowledge. I was diagnosed with dyslexia and had the symptoms of attention deficit disorder. Academic information just didn’t get through to me. Here are samples of reports that my teachers sent home when I was ten:

  • “He tends to dream in the middle of a calculation which leads him to lose track of the thought.”
  • “Has not paid much attention. Appears to know more of the Universe than the Earth.” (This was a veiled reference to daydreaming from my Geography teacher.)
  • “Terribly slow. Often cannot repeat the question. Must concentrate.”
  • “Unless Dominic really shakes himself up and gets down to work, he is not going to achieve any success . . . he is painfully slow.”

The comments contained no evidence that I would one day become an eight-time World Memory Champion and author of over a dozen books and courses on memory training. So what happened?

In 1987, aged 30, I watched a man on television memorize a shuffled deck of playing cards in just under three minutes. As corny as it may sound, that moment changed my life.

I taught myself to memorize playing cards and realized that the strategy I was developing could be used to remember anything. Today, when I appear on TV and radio shows all over the world, one question is always asked: “Why don’t they teach this stuff in schools?” Had I acquired those skills when I was at school, I would have achieved exam success, gone onto higher education, and actually enjoyed the learning process. Instead, I suffered low self-esteem and dropped out of school when I was 16.

Schools Memory Championships

In 2008, I co-founded the U.K. Schools Memory Championships along with Tony Buzan, the inventor of mind-mapping, and chess Grandmaster Raymond Keene. Rather than just going into a school and entertaining students with a few memory tricks, the aim was to embed powerful memory techniques into the minds of students by getting them to play “The Game of Memory” for themselves. These memory workshops are proven to boost young people’s self esteem, confidence and motivation to learn, and they provide tools to help improve overall achievement and exam performance.

Thinking back to when I was at school, I don’t recall a single lesson devoted entirely to the subject of memory. I can vaguely remember being given the acronym “Richard Of York Goes Battling In Vain” to remember the colors of the rainbow, but that was about it.

Having helped establish the teaching of memory skills the U.K. schools, I now find it completely illogical to expect a child to learn any subject without first teaching how to learn and how to remember. Read more…